The recent development of mammalian target of rapamycin (mTOR) kinase domain inhibitors and genetic dissection of rapamycin-sensitive and -insensitive mTOR protein complexes (mTORC1 and mTORC2) have revealed that phosphorylation of the mTOR substrate 4E-BP1 on amino acids Thr37 and/or Thr46 represents a rapamycin-insensitive activity of mTORC1.Desp
Journalism has always remained a vital constituent of our society and journalists play a key role in making people aware of the happenings and developments in society.This spread of information enables shaping the ideologies, orientations and thoughts of individuals as well as the society.Contrary to this, the spread of misinformation or fake news
BackgroundGlucose-6-phosphate isomerase (GPI) plays an important role in glycolysis and gluconeogenesis.However, the role of GPI in lung adenocarcinoma (LUAD) remains unclear.MethodsAll original data were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases and integrated via R 3.2.2.GPI expression was explored
Antifungal-lock therapy (AfLT) has arrived as an investigational approach for preventing catheter removal with limited Speaker Cable clinical evidence of its efficiency.The principle of AfLT consists of catheter lumen replenishment by a selected antimicrobial agent and then locking it for an alternative treatment to eradicate the microbes embedded